| Gene Information | |
|---|---|
| Gene Name | CLEC4M |
| Organism | Homo sapiens (Human) |
| Gene Length | 399 |
| Protein Names | C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 25 ( ENSG00000104938 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9H2X3 |
| Gene Card | CLEC4M |
| Uniprot ID | Q9H2X3 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.540191771) |
| Ortholog in Animals | Alpaca_ CLEC4M ( ortholog_one2one ) Dog_ CD209 ( ortholog_many2many ) Mouse_ Cd209g ( ortholog_many2many ) Mouse_ Cd209f ( ortholog_many2many ) Pig_ CD209 ( ortholog_many2many ) Rat_ Cd209f ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | ASGR1, CLEC4G, CLEC4C, CLEC17A, ASGR2, CLEC4A, CLEC4F, CLEC10A, CLEC6A, FCER2, CD209, CLEC4D, CD207, CLEC4E |
| Tissue | liver, lymph.node |
| Tissue Specificity | Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells. {ECO:0000269|PubMed:11226297, ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:15496474}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1K9J (X-ray 1.90A ) 1SL6 (X-ray 2.25A ) 1XAR (X-ray 2.25A ) 1XPH (X-ray 1.41A ) 3JQH (X-ray 2.20A ) |
| DBSNP | rs11465376 rs479448 rs479448 rs2277998 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 3]: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.; [Isoform 5]: Secreted {ECO:0000305}.; [Isoform 6]: Secreted {ECO:0000305}.; [Isoform 7]: Secreted {ECO:0000305}.; [Isoform 10]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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