| Gene Information | |
|---|---|
| Gene Name | ITGAB |
| Organism | Homo sapiens (Human) |
| Gene Length | 1039 |
| Protein Names | Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P08514 |
| Gene Card | ITGA2B |
| Uniprot ID | P08514 |
| Pfam | PF01839; PF00357; PF08441 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974). {ECO:0000269|PubMed:2351656, ECO:0000269|PubMed:9809974}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1DPK (NMR - ) 1DPQ (NMR - ) 1KUP (NMR - ) 1KUZ (NMR - ) 1M8O (NMR - ) 1S4W (NMR - ) 1TYE (X-ray 2.90A ) 2K1A (NMR - ) 2K9J (NMR - ) 2KNC (NMR - ) 2MTP (NMR - ) 2N9Y (NMR - ) 2VC2 (X-ray 3.10A ) 2VDK (X-ray 2.80A ) 2VDL (X-ray 2.75A ) 2VDM (X-ray 2.90A ) 2VDN (X-ray 2.90A ) 2VDO (X-ray 2.51A ) 2VDP (X-ray 2.80A ) 2VDQ (X-ray 2.59A ) 2VDR (X-ray 2.40A ) 3FCS (X-ray 2.55A ) 3FCU (X-ray 2.90A ) 3NID (X-ray 2.30A ) 3NIF (X-ray 2.40A ) 3NIG (X-ray 2.25A ) 3T3M (X-ray 2.60A ) 3T3P (X-ray 2.20A ) 3ZDX (X-ray 2.45A ) 3ZDY (X-ray 2.45A ) 3ZDZ (X-ray 2.75A ) 3ZE0 (X-ray 2.95A ) 3ZE1 (X-ray 3.00A ) 3ZE2 (X-ray 2.35A ) 4CAK (EM 20.50A ) 4Z7N (X-ray 2.60A ) 4Z7O (X-ray 2.85A ) 4Z7Q (X-ray 2.70A ) 5HDB (X-ray 2.70A ) 6V4P (EM 2.80A ) 7KN0 (NMR - ) 7L8P (X-ray 2.35A ) 7LA4 (EM 3.30A ) 7TCT (X-ray 2.50A ) 7TD8 (X-ray 2.60A ) 7THO (X-ray 2.75A ) 7TMZ (X-ray 2.20A ) 7TPD (X-ray 2.60A ) 7U60 (X-ray 2.55A ) 7U9F (X-ray 2.70A ) 7U9V (X-ray 2.25A ) 7UBR (X-ray 2.05A ) 7UCY (X-ray 2.35A ) 7UDG (X-ray 2.80A ) 7UDH (X-ray 2.00A ) 7UE0 (X-ray 2.74A ) 7UFH (X-ray 3.00A ) 7UH8 (X-ray 2.75A ) 7UJE (X-ray 2.50A ) 7UJK (X-ray 2.43A ) 7UK9 (X-ray 2.60A ) 7UKO (X-ray 2.60A ) 7UKP (X-ray 2.80A ) 7UKT (X-ray 2.37A ) |
| DBSNP | rs5915 rs1052533574 rs137852911 rs137852907 rs1126554 rs2048619428 rs137852910 rs137852908 rs766006685 rs75622274 rs780786843 rs1598380253 rs76811038 rs7207402 rs77961246 rs761174160 rs763762304 rs74475415 rs1344532070 rs5911 rs77458039 rs80002943 rs5914 rs78657866 rs78165611 rs879255514 rs766503255 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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