| Gene Information | |
|---|---|
| Gene Name | KCNAB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 419 |
| Protein Names | Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000169282 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q14722 |
| Gene Card | KCNAB1 |
| Uniprot ID | Q14722 |
| Pfam | PF00248 |
| In ASD | no |
| Allosteric Prediction | yes (0.237418132) |
| Ortholog in Animals | Alpaca_ KCNAB1 ( ortholog_one2one ) Dog_ KCNAB1 ( ortholog_one2one ) GuineaPig_ KCNAB1 ( ortholog_one2one ) Macaque_ KCNAB1 ( ortholog_one2one ) Mouse_ Kcnab1 ( ortholog_one2one ) Pig_ KCNAB1 ( ortholog_one2one ) Rat_ Kcnab1 ( ortholog_one2one ) Rabbit_ KCNAB1 ( ortholog_one2one ) |
| Ohnologs | KCNAB3, KCNAB2 |
| Paralogs | AKR1C8, AKR7A3, KCNAB3, AKR7A2, AKR1C3, AKR1C1, AKR1B1, AKR1E2, AKR1C4, AKR1A1, AKR1C2, AKR1B15, AKR1B10, KCNAB2, AKR7L, AKR1D1 |
| Tissue | thyroid |
| Tissue Specificity | In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium. {ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:8938711}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17540341}. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:17540341}; Peripheral membrane protein {ECO:0000269|PubMed:17540341}; Cytoplasmic side {ECO:0000269|PubMed:17540341}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000269|PubMed:17540341}. |
| Mouse PG classification | NA |
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