| Gene Information | |
|---|---|
| Gene Name | DEDD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000160570 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8WXF8 |
| Gene Card | DEDD2 |
| Uniprot ID | Q8WXF8 |
| Pfam | PF01335 |
| In ASD | no |
| Allosteric Prediction | no (-1.569011958) |
| Ortholog in Animals | Alpaca_ DEDD2 ( ortholog_one2one ) Dog_ DEDD2 ( ortholog_one2one ) GuineaPig_ DEDD2 ( ortholog_one2one ) Macaque_ DEDD2 ( ortholog_one2one ) Mouse_ Dedd2 ( ortholog_one2one ) Pig_ DEDD2 ( ortholog_one2one ) Rat_ Dedd2 ( ortholog_one2one ) Rabbit_ DEDD2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DEDD |
| Tissue | NA |
| Tissue Specificity | Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. {ECO:0000269|PubMed:11741985, ECO:0000269|PubMed:11965497}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:11965497}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli. |
| Mouse PG classification | NA |
| click here to return to the previous page | |