| Gene Information | |
|---|---|
| Gene Name | KRT85 |
| Organism | Homo sapiens (Human) |
| Gene Length | 507 |
| Protein Names | Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000135443 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P78386 |
| Gene Card | KRT85 |
| Uniprot ID | P78386 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-0.897277977) |
| Ortholog in Animals | Alpaca_ KRT85 ( ortholog_one2one ) Dog_ KRT85 ( ortholog_one2one ) GuineaPig_ KRT85 ( ortholog_one2one ) Macaque_ KRT85 ( ortholog_one2one ) Mouse_ Gm49425 ( ortholog_one2one ) Pig_ KRT85 ( ortholog_one2one ) Rat_ Krt85 ( ortholog_one2one ) Rabbit_ KRT85 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | zone.of.skin |
| Tissue Specificity | Synthesis occurs immediately above a small population of matrix cells at the base of the hair bulb and the trichocytes lining the dermal papilla and extends upward through the matrix and ends in the lower part of the cortex of the hair shaft. {ECO:0000269|PubMed:9084137}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs61630004 rs2852471 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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