| Gene Information | |
|---|---|
| Gene Name | KRT8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8) |
| Target Name | keratin, type ii cytoskeletal 8 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000170421 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P05787 |
| Gene Card | KRT8 |
| Uniprot ID | P05787 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-0.336042781) |
| Ortholog in Animals | Alpaca_ KRT8 ( ortholog_one2one ) Mouse_ Krt8 ( ortholog_one2one ) Pig_ KRT8 ( ortholog_one2one ) Rat_ Krt8 ( ortholog_one2one ) Rabbit_ KRT8 ( ortholog_one2one ) |
| Ohnologs | KRT33A, GFAP, KRT19, KRT15, KRT10, KRT17P2, KRT16, KRT14, VIM, DES |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | NA |
| Tissue Specificity | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:16000376}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7K3C (X-ray 1.10A ) 7K3X (X-ray 1.71A ) 7K3Y (X-ray 1.10A ) |
| DBSNP | rs61710484 rs11554495 rs59536457 rs2277330 rs1065648 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:19188445}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q10758}. Nucleus matrix {ECO:0000250|UniProtKB:Q10758}. |
| Mouse PG classification | NA |
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