| Gene Information | |
|---|---|
| Gene Name | KAT5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) |
| Target Name | histone acetyltransferase kat5 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000172977 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92993 |
| Gene Card | KAT5 |
| Uniprot ID | Q92993 |
| Pfam | PF01853; PF11717; PF17772 |
| In ASD | no |
| Allosteric Prediction | yes (0.473773748) |
| Ortholog in Animals | Alpaca_ KAT5 ( ortholog_one2one ) Dog_ KAT5 ( ortholog_one2one ) GuineaPig_ KAT5 ( ortholog_one2one ) Macaque_ KAT5 ( ortholog_one2one ) Mouse_ Kat5 ( ortholog_one2one ) Pig_ KAT5 ( ortholog_one2one ) Rat_ Kat5 ( ortholog_one2one ) Rabbit_ KAT5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KAT8, KAT6B, KAT6A, PHF10, KAT7, DPF1, DPF3, DPF2, RSF1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2EKO (NMR - ) 2OU2 (X-ray 2.30A ) 4QQG (X-ray 2.80A ) |
| DBSNP | rs1857071943 rs11541271 rs1857290083 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:11416127, ECO:0000269|PubMed:12551922, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17704809, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:25301942, ECO:0000269|PubMed:33938178}. Chromosome {ECO:0000269|PubMed:25560918, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:33076429}. Cytoplasm {ECO:0000269|PubMed:25301942}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:26829474}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:34608293}. Nucleus, nucleolus {ECO:0000269|PubMed:16387653}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11262386}. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386). Transiently localizes to kinetochores in early mitosis (PubMed:26829474). Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293). Localizes in the cytoplasm and nucleus of round spermatids (By similarity). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:34608293}. |
| Mouse PG classification | NA |
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