Gene Information
Gene NameKRT74
OrganismHomo sapiens (Human)
Gene Length529
Protein NamesKeratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000170484 )
Evolutionary StageEukaryota
AlphaFoldDBQ7RTS7
Gene CardKRT74
Uniprot IDQ7RTS7
PfamPF00038; PF16208
In ASDno
Allosteric Predictionno (-1.07999882)
Ortholog in AnimalsAlpaca_ KRT74 ( ortholog_one2one )
Dog_ KRT74 ( ortholog_one2one )
GuineaPig_ KRT74 ( ortholog_one2one )
Macaque_ KRT74 ( ortholog_one2one )
Pig_ KRT74 ( ortholog_one2one )
OhnologsNA
ParalogsVIM, KRT12, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10
TissueNA
Tissue SpecificityHighly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level). {ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310, ECO:0000269|PubMed:24714551}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs267607205  rs11170177  rs11170176  rs670741  rs147962513  rs57387512  rs57711382  rs267607477 
Subcellular location [CC]NA
Mouse PG classificationNA
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