| Gene Information | |
|---|---|
| Gene Name | KRT72 |
| Organism | Homo sapiens (Human) |
| Gene Length | 511 |
| Protein Names | Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000170486 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14CN4 |
| Gene Card | KRT72 |
| Uniprot ID | Q14CN4 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-1.446726868) |
| Ortholog in Animals | Alpaca_ KRT72 ( ortholog_one2one ) Dog_ KRT72 ( ortholog_one2one ) GuineaPig_ KRT72 ( ortholog_one2one ) Mouse_ Krt72 ( ortholog_one2one ) Pig_ KRT72 ( ortholog_one2one ) Rat_ Krt72 ( ortholog_one2one ) Rabbit_ KRT72 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | testis, small.intestine |
| Tissue Specificity | Highly expressed in hair follicles from scalp and eyebrow. Also expressed in palmoplantar epidermis. Not expressed in face skin despite the presence of fine hairs histologically. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, its presence is delayed up to the height of the apex of the dermal papilla (at protein level). {ECO:0000269|PubMed:11703281, ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11170187 rs12833456 rs34769047 rs7310138 rs11170183 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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