| Gene Information | |
|---|---|
| Gene Name | KRT71 |
| Organism | Homo sapiens (Human) |
| Gene Length | 523 |
| Protein Names | Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000139648 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q3SY84 |
| Gene Card | KRT71 |
| Uniprot ID | Q3SY84 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-1.266595527) |
| Ortholog in Animals | Alpaca_ KRT71 ( ortholog_one2one ) GuineaPig_ KRT71 ( ortholog_one2one ) Macaque_ KRT71 ( ortholog_one2one ) Mouse_ Krt71 ( ortholog_one2one ) Pig_ KRT71 ( ortholog_one2one ) Rat_ Krt71 ( ortholog_one2one ) Rabbit_ KRT71 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | zone.of.skin |
| Tissue Specificity | Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level). {ECO:0000269|PubMed:11982755, ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310, ECO:0000269|PubMed:22592156}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs665522 rs665470 rs587777545 rs35988863 rs10783518 rs2292506 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22592156}. |
| Mouse PG classification | HPG |
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