| Gene Information | |
|---|---|
| Gene Name | KRT7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 469 |
| Protein Names | Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7) |
| Target Name | keratin, type ii cytoskeletal 7 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000135480 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P08729 |
| Gene Card | KRT7 |
| Uniprot ID | P08729 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-0.44704172) |
| Ortholog in Animals | Alpaca_ KRT7 ( ortholog_one2one ) GuineaPig_ KRT7 ( ortholog_one2one ) Macaque_ KRT7 ( ortholog_one2one ) Mouse_ Krt7 ( ortholog_one2one ) Pig_ KRT7 ( ortholog_one2one ) Rat_ Krt7 ( ortholog_one2one ) Rabbit_ KRT7 ( ortholog_one2one ) |
| Ohnologs | KRT33A, GFAP, KRT19, KRT15, KRT10, KRT17P2, KRT16, KRT14, VIM, DES |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | kidney, lung, pancreas, minor.salivary.gland |
| Tissue Specificity | Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus. {ECO:0000269|PubMed:12359226, ECO:0000269|PubMed:2415537}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4XIF (X-ray 3.20A ) |
| DBSNP | rs6580870 rs2608009 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:2459129}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |