| Gene Information | |
|---|---|
| Gene Name | SLC9A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 798 |
| Protein Names | Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000180251 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q6AI14 |
| Gene Card | SLC9A4 |
| Uniprot ID | Q6AI14 |
| Pfam | PF00999; PF16644 |
| In ASD | no |
| Allosteric Prediction | no (-0.150470045) |
| Ortholog in Animals | Alpaca_ SLC9A4 ( ortholog_one2one ) Dog_ SLC9A4 ( ortholog_one2one ) GuineaPig_ SLC9A4 ( ortholog_one2one ) Macaque_ SLC9A4 ( ortholog_one2one ) Mouse_ Slc9a4 ( ortholog_one2one ) Pig_ SLC9A4 ( ortholog_one2one ) Rat_ Slc9a4 ( ortholog_one2one ) Rabbit_ SLC9A4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC9A7, SLC9A6, SLC9C1, SLC9A1, SLC9A9, SLC9A5, SLC9A3, SLC9A2, SLC9A8, SLC9C2 |
| Tissue | stomach |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17027275 rs6742280 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q8BUE1}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Note=Enrichment at apical or basolateral membrane may be tissue-dependent. {ECO:0000250|UniProtKB:P26434}. |
| Mouse PG classification | NA |
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