| Gene Information | |
|---|---|
| Gene Name | KRT4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000170477 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P19013 |
| Gene Card | KRT4 |
| Uniprot ID | P19013 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-1.619613687) |
| Ortholog in Animals | Alpaca_ KRT4 ( ortholog_one2one ) GuineaPig_ KRT4 ( ortholog_one2one ) Macaque_ KRT4 ( ortholog_one2one ) Mouse_ Krt4 ( ortholog_one2one ) Pig_ KRT4 ( ortholog_one2one ) Rat_ Krt4 ( ortholog_one2one ) |
| Ohnologs | KRT33A, GFAP, KRT19, KRT15, KRT10, KRT17P2, KRT16, KRT14, VIM, DES |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | esophagus, tongue, esophagus.mucosa |
| Tissue Specificity | Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. {ECO:0000269|PubMed:2452170}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2638525 rs62642055 |
| Subcellular location [CC] | NA |
| Mouse PG classification | HPG |
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