| Gene Information | |
|---|---|
| Gene Name | KRT28 |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | Keratin, type I cytoskeletal 28 (Cytokeratin-28) (CK-28) (Keratin-25D) (K25D) (Keratin-28) (K28) (Type I inner root sheath-specific keratin-K25irs4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000173908 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z3Y7 |
| Gene Card | KRT28 |
| Uniprot ID | Q7Z3Y7 |
| Pfam | PF00038 |
| In ASD | no |
| Allosteric Prediction | no (-1.513445193) |
| Ortholog in Animals | Alpaca_ KRT28 ( ortholog_one2one ) Dog_ KRT28 ( ortholog_one2one ) GuineaPig_ KRT28 ( ortholog_one2one ) Macaque_ KRT28 ( ortholog_one2one ) Mouse_ Krt28 ( ortholog_one2one ) Pig_ KRT28 ( ortholog_one2one ) Rat_ Krt28 ( ortholog_one2one ) Rabbit_ KRT28 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level). {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:16874310}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7209228 rs4624233 rs17558995 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |