| Gene Information | |
|---|---|
| Gene Name | KRT27 |
| Organism | Homo sapiens (Human) |
| Gene Length | 459 |
| Protein Names | Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000171446 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z3Y8 |
| Gene Card | KRT27 |
| Uniprot ID | Q7Z3Y8 |
| Pfam | PF00038 |
| In ASD | no |
| Allosteric Prediction | no (-1.774569738) |
| Ortholog in Animals | Alpaca_ KRT27 ( ortholog_one2one ) Dog_ KRT27 ( ortholog_one2one ) GuineaPig_ KRT27 ( ortholog_one2one ) Macaque_ KRT27 ( ortholog_one2one ) Mouse_ Krt27 ( ortholog_one2one ) Pig_ KRT27 ( ortholog_one2one ) Rat_ Krt27 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | zone.of.skin |
| Tissue Specificity | Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level). {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:16874310}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2469826 rs12453124 rs17558560 rs17558532 rs981684 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9Z320}. |
| Mouse PG classification | NA |
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