Gene Information
Gene NameKRT25
OrganismHomo sapiens (Human)
Gene Length450
Protein NamesKeratin, type I cytoskeletal 25 (Cytokeratin-25) (CK-25) (Keratin-25) (K25) (Keratin-25A) (K25A) (Type I inner root sheath-specific keratin-K25irs1)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000204897 )
Evolutionary StageEumetazoa
AlphaFoldDBQ7Z3Z0
Gene CardKRT25
Uniprot IDQ7Z3Z0
PfamPF00038
In ASDno
Allosteric Predictionno (-0.892012378)
Ortholog in AnimalsAlpaca_ KRT25 ( ortholog_one2one )
Dog_ KRT25 ( ortholog_one2one )
GuineaPig_ KRT25 ( ortholog_one2one )
Macaque_ KRT25 ( ortholog_one2one )
Mouse_ Krt25 ( ortholog_one2one )
Pig_ KRT25 ( ortholog_one2one )
Rat_ Krt25 ( ortholog_one2one )
Rabbit_ KRT25 ( ortholog_one2one )
OhnologsNA
ParalogsVIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10
Tissuezone.of.skin
Tissue SpecificityStrongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level). {ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:16874310}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs12951399  rs879253749  rs766783183 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:Q8VCW2}.
Mouse PG classificationHPG
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