| Gene Information | |
|---|---|
| Gene Name | KRT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 639 |
| Protein Names | Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2) |
| Target Name | keratin, type ii cytoskeletal 2 epidermal |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000172867 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P35908 |
| Gene Card | KRT2 |
| Uniprot ID | P35908 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-0.35759941) |
| Ortholog in Animals | Alpaca_ KRT2 ( ortholog_one2one ) GuineaPig_ KRT2 ( ortholog_one2one ) Macaque_ KRT2 ( ortholog_one2one ) Mouse_ Krt2 ( ortholog_one2one ) Pig_ KRT2 ( ortholog_one2one ) Rat_ Krt2 ( ortholog_one2one ) Rabbit_ KRT2 ( ortholog_one2one ) |
| Ohnologs | KRT33A, GFAP, KRT19, KRT15, KRT10, KRT17P2, KRT16, KRT14, VIM, DES |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | skin, lower.leg.skin |
| Tissue Specificity | Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization. {ECO:0000269|PubMed:10233306, ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2634041 rs57728941 rs57510142 rs61622714 rs137852631 rs137852632 rs137852631 rs638043 rs758760389 rs56829062 rs60537449 rs137852630 rs61726451 rs137852628 rs137852629 rs61726452 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32179842}. |
| Mouse PG classification | NA |
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