| Gene Information | |
|---|---|
| Gene Name | KRT19 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171345 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08727 |
| Gene Card | KRT19 |
| Uniprot ID | P08727 |
| Pfam | PF00038 |
| In ASD | no |
| Allosteric Prediction | no (-0.224929962) |
| Ortholog in Animals | Alpaca_ KRT19 ( ortholog_one2one ) GuineaPig_ KRT19 ( ortholog_one2one ) Macaque_ KRT19 ( ortholog_one2one ) Mouse_ Krt19 ( ortholog_one2one ) Pig_ KRT19 ( ortholog_one2one ) |
| Ohnologs | VIM, NEFM, KRT18, PRPH, KRT7, INA, KRT84, KRT82, KRT1, KRT8, KRT86, KRT75, KRT6C, KRT4, KRT83, KRT2, DES, KRT6B, KRT79, KRT5, KRT77, KRT6A |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | NA |
| Tissue Specificity | Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. {ECO:0000269|PubMed:16000376, ECO:0000269|PubMed:2468493, ECO:0000269|PubMed:2469734}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs4602 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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