| Gene Information | |
|---|---|
| Gene Name | KRT14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 472 |
| Protein Names | Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) |
| Target Name | keratin, type i cytoskeletal 14 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000186847 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P02533 |
| Gene Card | KRT14 |
| Uniprot ID | P02533 |
| Pfam | PF00038 |
| In ASD | no |
| Allosteric Prediction | no (-0.802695083) |
| Ortholog in Animals | Alpaca_ KRT14 ( ortholog_one2one ) Dog_ KRT15 ( ortholog_one2one ) GuineaPig_ KRT14 ( ortholog_one2one ) Mouse_ Krt14 ( ortholog_one2one ) |
| Ohnologs | VIM, NEFM, KRT18, PRPH, KRT7, INA, KRT84, KRT82, KRT80, KRT1, KRT8, KRT86, KRT75, KRT6C, KRT4, KRT83, KRT2, DES, KRT6B, KRT79, KRT5, KRT77, KRT6A |
| Paralogs | KRT16, VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Expressed in the corneal epithelium (at protein level) (PubMed:26758872). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair (PubMed:9457912). Found in keratinocytes surrounding the club hair during telogen (PubMed:9457912). {ECO:0000269|PubMed:26758872, ECO:0000269|PubMed:9457912}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3TNU (X-ray 3.00A ) 6JFV (X-ray 2.60A ) |
| DBSNP | rs6503640 rs3826550 rs59271739 rs57358989 rs28928893 rs61263401 rs60993843 rs59110575 rs3826549 rs60171927 rs60399023 rs60399023 rs58330629 rs58330629 rs60470268 rs57522245 rs1555603282 rs61027685 rs61027685 rs61540016 rs61326242 rs57121345 rs58378809 rs60589227 rs11551755 rs147611635 rs58560979 rs61371557 rs61371557 rs59375065 rs58785777 rs56974573 rs61536893 rs61536893 rs59629244 rs59966597 rs58645163 rs57200223 rs267607389 rs267607403 rs59780231 rs59442925 rs58380626 rs60622724 rs61085704 rs57364972 rs58762773 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11724817, ECO:0000269|PubMed:31995743, ECO:0000269|PubMed:32179842}. Nucleus {ECO:0000269|PubMed:11724817}. Note=Expressed in both as a filamentous pattern. {ECO:0000269|PubMed:11724817}. |
| Mouse PG classification | HPG |
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