| Gene Information | |
|---|---|
| Gene Name | KRT10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 584 |
| Protein Names | Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) |
| Target Name | keratin, type i cytoskeletal 10 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000186395 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P13645 |
| Gene Card | KRT10 |
| Uniprot ID | P13645 |
| Pfam | PF00038 |
| In ASD | no |
| Allosteric Prediction | no (-0.41764225) |
| Ortholog in Animals | Alpaca_ KRT10 ( ortholog_one2one ) Dog_ KRT10 ( ortholog_one2one ) Macaque_ KRT10 ( ortholog_one2one ) Mouse_ Krt10 ( ortholog_one2one ) Pig_ KRT10 ( ortholog_one2one ) Rat_ Krt10 ( ortholog_one2one ) Rabbit_ KRT10 ( ortholog_one2one ) |
| Ohnologs | VIM, NEFM, KRT18, PRPH, KRT7, INA, KRT84, KRT82, KRT1, KRT8, KRT86, KRT75, KRT6C, KRT4, KRT83, KRT2, DES, KRT6B, KRT79, KRT5, KRT77, KRT6A |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18 |
| Tissue | NA |
| Tissue Specificity | Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498). Localized on the surface of desquamated nasal epithelial cells (at protein level) (PubMed:12427098). {ECO:0000269|PubMed:12427098, ECO:0000269|PubMed:19627498}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ASW (X-ray 2.60A ) 4F1Z (X-ray 2.30A ) 4ZRY (X-ray 3.30A ) 6E2J (X-ray 2.39A ) 6EC0 (X-ray 2.98A ) 6UUI (X-ray 2.07A ) |
| DBSNP | rs4261597 rs77919366 rs58901407 rs58901407 rs57784225 rs58852768 rs58075662 rs58075662 rs58852768 rs58414354 rs58735429 rs60118264 rs59075499 rs61434181 rs58026994 rs62651994 rs267607383 rs17855579 |
| Subcellular location [CC] | Secreted, extracellular space {ECO:0000269|PubMed:12427098}. Cell surface {ECO:0000269|PubMed:19627498}. Cytoplasm {ECO:0000269|PubMed:32179842}. |
| Mouse PG classification | HPG |
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