| Gene Information | |
|---|---|
| Gene Name | KRT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 644 |
| Protein Names | Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1) |
| Target Name | keratin, type ii cytoskeletal 1 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000167768 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P04264 |
| Gene Card | KRT1 |
| Uniprot ID | P04264 |
| Pfam | PF00038; PF16208; PF16210 |
| In ASD | no |
| Allosteric Prediction | no (-0.114682205) |
| Ortholog in Animals | Alpaca_ KRT1 ( ortholog_one2one ) GuineaPig_ KRT1 ( ortholog_one2one ) Macaque_ KRT1 ( ortholog_one2one ) Mouse_ Krt1 ( ortholog_one2one ) Pig_ KRT1 ( ortholog_one2one ) Rat_ Krt1 ( ortholog_one2one ) Rabbit_ KRT1 ( ortholog_one2one ) |
| Ohnologs | KRT33A, GFAP, KRT19, KRT15, KRT10, KRT17P2, KRT16, KRT14, VIM, DES |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | skin, zone.of.skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4ZRY (X-ray 3.30A ) 6E2J (X-ray 2.39A ) 6UUI (X-ray 2.07A ) |
| DBSNP | rs57977969 rs57959072 rs57959072 rs57695159 rs60022878 rs59429455 rs58928370 rs58928370 rs60937700 rs61549035 rs58062863 rs1050872 rs17678945 rs59089201 rs61218439 rs57837128 rs58420087 rs267607430 rs56914602 rs60279707 rs60279707 rs14024 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17956333}. Cytoplasm {ECO:0000269|PubMed:32179842}. |
| Mouse PG classification | HPG |
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