Gene Information
Gene NameEED
OrganismHomo sapiens (Human)
Gene Length441
Protein NamesPolycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Target Nameembryonic ectoderm development protein
Target TypeClinical trial target
Gene Age1714 ( ENSG00000074266 )
Evolutionary StageEukaryota
AlphaFoldDBO75530
Gene CardEED
Uniprot IDO75530
PfamPF00400
In ASDyes
Allosteric Predictionyes (0.999941447)
Ortholog in AnimalsAlpaca_ EED ( ortholog_one2one )
Dog_ EED ( ortholog_one2one )
GuineaPig_ EED ( ortholog_one2one )
Macaque_ EED ( ortholog_one2one )
Mouse_ Eed ( ortholog_one2one )
Pig_ EED ( ortholog_one2one )
Rat_ Eed ( ortholog_one2one )
Rabbit_ EED ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:9584199, ECO:0000269|PubMed:9765275, ECO:0000269|PubMed:9806832, ECO:0000269|PubMed:9880543}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.007310(Rat);0.058420(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3IIW  (X-ray  1.80A  3IIY  (X-ray  2.65A  3IJ0  (X-ray  2.45A  3IJ1  (X-ray  2.10A  3IJC  (X-ray  1.95A  3JPX  (X-ray  2.05A  3JZG  (X-ray  2.10A  3JZH  (X-ray  2.05A  3JZN  (X-ray  2.60A  3K26  (X-ray  1.58A  3K27  (X-ray  1.76A  4W2R  (X-ray  2.81A  4X3E  (X-ray  2.30A  5GSA  (X-ray  2.49A  5H13  (X-ray  1.90A  5H14  (X-ray  1.90A  5H15  (X-ray  2.27A  5H17  (X-ray  2.30A  5H19  (X-ray  1.90A  5H24  (X-ray  2.50A  5H25  (X-ray  2.88A  5HYN  (X-ray  2.95A  5IJ7  (X-ray  2.62A  5IJ8  (X-ray  2.99A  5K0M  (X-ray  1.83A  5LS6  (X-ray  3.47A  5TTW  (X-ray  1.74A  5U5H  (X-ray  1.80A  5U5K  (X-ray  2.33A  5U5T  (X-ray  1.60A  5U62  (X-ray  1.90A  5U69  (X-ray  1.28A  5U6D  (X-ray  1.64A  5U8A  (X-ray  1.45A  5U8F  (X-ray  1.34A  5WG6  (X-ray  3.90A  5WP3  (X-ray  2.55A  5WUK  (X-ray  2.03A  6B3W  (X-ray  3.05A  6C23  (EM  3.90A  6C24  (EM  3.50A  6LO2  (X-ray  2.21A  6SFB  (X-ray  1.52A  6SFC  (X-ray  2.00A  6U4Y  (X-ray  2.91A  6V3X  (X-ray  1.70A  6V3Y  (X-ray  1.63A  6W7F  (X-ray  2.20A  6W7G  (X-ray  1.85A  6WKR  (EM  3.50A  6YVI  (X-ray  2.26A  6YVJ  (X-ray  1.84A  7KSO  (EM  3.90A  7KSR  (EM  4.10A  7KTP  (EM  4.80A  7KXT  (X-ray  2.15A  7MSB  (X-ray  1.90A  7MSD  (X-ray  2.20A  7P3C  (X-ray  1.61A  7P3G  (X-ray  2.39A  7P3J  (X-ray  1.93A  7QJG  (X-ray  1.80A  7QJU  (X-ray  1.80A  7QK4  (X-ray  1.60A 
DBSNP rs1131692176  rs1131692174  rs1131692175  rs1131692173 
Subcellular location [CC]Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
Mouse PG classificationNA
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