Gene Information
Gene NameDAGLA
OrganismHomo sapiens (Human)
Gene Length1042
Protein NamesDiacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha)
Target Namesn1-specific diacylglycerol lipase alpha
Target TypeNA
Gene Age645 ( ENSG00000134780 )
Evolutionary StageEukaryota
AlphaFoldDBQ9Y4D2
Gene CardDAGLA
Uniprot IDQ9Y4D2
PfamPF01764
In ASDno
Allosteric Predictionno (-1.000310982)
Ortholog in AnimalsAlpaca_ DAGLA ( ortholog_one2one )
Dog_ DAGLA ( ortholog_one2one )
GuineaPig_ DAGLA ( ortholog_one2one )
Macaque_ DAGLA ( ortholog_one2one )
Mouse_ Dagla ( ortholog_one2one )
Pig_ DAGLA ( ortholog_one2one )
Rat_ Dagla ( ortholog_one2one )
Rabbit_ DAGLA ( ortholog_one2one )
OhnologsNA
ParalogsDAGLB, GOLT1B, GOLT1A
TissueNA
Tissue SpecificityHighly expressed in brain and pancreas. {ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:16051747}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs35056845  rs3741252  rs34956386 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:27595600};
Multi-pass membrane protein {ECO:0000255}. Postsynaptic density membrane {ECO:0000269|PubMed:27595600};
Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:27595600};
Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q6WQJ1};
Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner. {ECO:0000269|PubMed:27595600}.
Mouse PG classificationNA
click here to return to the previous page