Gene Information
Gene NameERBB2
OrganismHomo sapiens (Human)
Gene Length1255
Protein NamesReceptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Target Namereceptor tyrosine-protein kinase erbb-2
Target TypeNA
Gene Age645 ( ENSG00000141736 )
Evolutionary StageOpisthokonta
AlphaFoldDBP04626
Gene CardERBB2
Uniprot IDP04626
PfamPF00757; PF14843; PF07714; PF01030
In ASDyes
Allosteric Predictionyes (1.175174165)
Ortholog in AnimalsAlpaca_ ERBB2 ( ortholog_one2one )
Dog_ ERBB2 ( ortholog_one2one )
GuineaPig_ ERBB2 ( ortholog_one2one )
Macaque_ ERBB2 ( ortholog_one2one )
Mouse_ Erbb2 ( ortholog_one2one )
Pig_ ERBB2 ( ortholog_one2one )
Rat_ Erbb2 ( ortholog_one2one )
Rabbit_ ERBB2 ( ortholog_one2one )
OhnologsERBB3, EGFR, ERBB4
ParalogsEPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
TissueNA
Tissue SpecificityExpressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269|PubMed:15380516}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.391370(Rat);0.112943(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1MFG  (X-ray  1.25A  )  1MFL  (X-ray  1.88A  )  1MW4  (NMR  -  )  1N8Z  (X-ray  2.52A  )  1QR1  (X-ray  2.40A  )  1S78  (X-ray  3.25A  )  2A91  (X-ray  2.50A  )  2JWA  (NMR  -  )  2KS1  (NMR  -  )  2L4K  (NMR  -  )  2N2A  (NMR  -  )  3BE1  (X-ray  2.90A  )  3H3B  (X-ray  2.45A  )  3MZW  (X-ray  2.90A  )  3N85  (X-ray  3.20A  )  3PP0  (X-ray  2.25A  )  3RCD  (X-ray  3.21A  )  3WLW  (X-ray  3.09A  )  3WSQ  (X-ray  3.50A  )  4GFU  (X-ray  2.00A  )  4HRL  (X-ray  2.55A  )  4HRM  (X-ray  3.20A  )  4HRN  (X-ray  2.65A  )  4NND  (X-ray  2.50A  )  5K33  (X-ray  3.30A  )  5KWG  (X-ray  4.30A  )  5MY6  (X-ray  2.25A  )  5O4G  (X-ray  3.00A  )  5OB4  (NMR  -  )  5TQS  (X-ray  1.88A  )  6ATT  (X-ray  3.77A  )  6BGT  (X-ray  2.70A  )  6J71  (X-ray  2.92A  )  6LBX  (X-ray  2.03A  )  6OGE  (EM  4.36A  )  7JXH  (X-ray  3.27A  )  7MN5  (EM  2.93A  )  7MN6  (EM  3.09A  )  7MN8  (EM  3.45A  )  7PCD  (X-ray  1.77A  ) 
DBSNP rs4252633  rs1801201  rs1136201  rs121913469  rs56366519  rs28933369  rs28933370  rs28933368  rs1058808  rs55943169 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:32381043};
Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000269|PubMed:34380438};
Single-pass type I membrane protein {ECO:0000255}. Note=Internalized from the cell membrane in response to EGF stimulation. {ECO:0000269|PubMed:32381043}.;
[Isoform 1]: Cell membrane {ECO:0000269|PubMed:31138794, ECO:0000269|PubMed:33497358};
Single-pass type I membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:31138794}. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). {ECO:0000269|PubMed:31138794}.;
[Isoform 2]: Cytoplasm. Nucleus.;
[Isoform 3]: Cytoplasm. Nucleus.
Mouse PG classificationHPG
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