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Gene Information
Gene Name
KRAS2
Organism
Homo sapiens (Human)
Gene Length
189
Protein Names
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
P01116
Gene Card
KRAS
Uniprot ID
P01116
Pfam
PF00071
In ASD
no
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.181662(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1D8D
(X-ray
2.00A
)
1D8E
(X-ray
3.00A
)
1KZO
(X-ray
2.20A
)
1KZP
(X-ray
2.10A
)
1N4P
(X-ray
2.65A
)
1N4Q
(X-ray
2.40A
)
1N4R
(X-ray
2.80A
)
1N4S
(X-ray
2.60A
)
3GFT
(X-ray
2.27A
)
4DSN
(X-ray
2.03A
)
4DSO
(X-ray
1.85A
)
4EPR
(X-ray
2.00A
)
4EPT
(X-ray
2.00A
)
4EPV
(X-ray
1.35A
)
4EPW
(X-ray
1.70A
)
4EPX
(X-ray
1.76A
)
4EPY
(X-ray
1.80A
)
4L8G
(X-ray
1.52A
)
4LDJ
(X-ray
1.15A
)
4LPK
(X-ray
1.50A
)
4LRW
(X-ray
2.15A
)
4LUC
(X-ray
1.29A
)
4LV6
(X-ray
1.50A
)
4LYF
(X-ray
1.57A
)
4LYH
(X-ray
1.37A
)
4LYJ
(X-ray
1.93A
)
4M1O
(X-ray
1.57A
)
4M1S
(X-ray
1.55A
)
4M1T
(X-ray
1.70A
)
4M1W
(X-ray
1.58A
)
4M1Y
(X-ray
1.49A
)
4M21
(X-ray
1.94A
)
4M22
(X-ray
2.09A
)
4NMM
(X-ray
1.89A
)
4OBE
(X-ray
1.24A
)
4PZY
(X-ray
1.88A
)
4PZZ
(X-ray
1.40A
)
4Q01
(X-ray
1.29A
)
4Q02
(X-ray
1.70A
)
4Q03
(X-ray
1.20A
)
4QL3
(X-ray
1.04A
)
4TQ9
(X-ray
1.49A
)
4TQA
(X-ray
1.13A
)
4WA7
(X-ray
1.99A
)
5F2E
(X-ray
1.40A
)
5KYK
(X-ray
2.70A
)
5MLA
(X-ray
2.19A
)
5MLB
(X-ray
3.22A
)
5O2S
(X-ray
3.22A
)
5O2T
(X-ray
2.19A
)
5OCG
(X-ray
1.48A
)
5OCO
(X-ray
1.66A
)
5OCT
(X-ray
2.07A
)
5TAR
(X-ray
1.90A
)
5TB5
(X-ray
2.00A
)
5UFE
(X-ray
2.30A
)
5UFQ
(X-ray
2.20A
)
5UK9
(X-ray
1.89A
)
5UQW
(X-ray
1.50A
)
5US4
(X-ray
1.83A
)
5USJ
(X-ray
1.94A
)
5V6S
(X-ray
1.70A
)
5V6V
(X-ray
1.72A
)
5V71
(X-ray
2.23A
)
5V9L
(X-ray
1.98A
)
5V9O
(X-ray
1.56A
)
5V9U
(X-ray
1.38A
)
5VBM
(X-ray
1.49A
)
5VP7
(X-ray
1.70A
)
5VPI
(X-ray
1.62A
)
5VPY
(X-ray
2.00A
)
5VPZ
(X-ray
1.85A
)
5VQ0
(X-ray
2.30A
)
5VQ1
(X-ray
1.78A
)
5VQ2
(X-ray
1.96A
)
5VQ6
(X-ray
1.99A
)
5VQ8
(X-ray
2.30A
)
5W22
(X-ray
1.76A
)
5WHA
(X-ray
2.04A
)
5WHB
(X-ray
2.18A
)
5WHD
(X-ray
1.64A
)
5WHE
(X-ray
1.91A
)
5WLB
(X-ray
1.72A
)
5WPM
(X-ray
1.72A
)
5XCO
(X-ray
1.25A
)
5YXZ
(X-ray
1.70A
)
5YY1
(X-ray
1.69A
)
6ARK
(X-ray
1.75A
)
6ASA
(X-ray
2.54A
)
6ASE
(X-ray
1.55A
)
6B0V
(X-ray
1.29A
)
6B0Y
(X-ray
1.43A
)
6BOF
(X-ray
1.40A
)
6BP1
(X-ray
2.00A
)
6CC9
(NMR
-
)
6CCH
(NMR
-
)
6CCX
(NMR
-
)
6CU6
(X-ray
1.50A
)
6E6F
(X-ray
3.40A
)
6E6G
(X-ray
1.93A
)
6EPL
(X-ray
2.55A
)
6EPM
(X-ray
2.50A
)
6EPN
(X-ray
2.50A
)
6EPO
(X-ray
2.40A
)
6EPP
(X-ray
2.40A
)
6F76
(X-ray
2.20A
)
6FA1
(X-ray
1.97A
)
6FA2
(X-ray
2.60A
)
6FA3
(X-ray
1.82A
)
6FA4
(X-ray
2.02A
)
6GJ5
(X-ray
1.50A
)
6GJ6
(X-ray
1.76A
)
6GJ7
(X-ray
1.67A
)
6GJ8
(X-ray
1.65A
)
6GOD
(X-ray
1.71A
)
6GOE
(X-ray
1.60A
)
6GOF
(X-ray
1.98A
)
6GOG
(X-ray
2.05A
)
6GOM
(X-ray
1.63A
)
6GQT
(X-ray
1.69A
)
6GQW
(X-ray
2.80A
)
6GQX
(X-ray
2.20A
)
6GQY
(X-ray
2.75A
)
6H46
(X-ray
2.22A
)
6H47
(X-ray
1.70A
)
6JTN
(X-ray
1.90A
)
6JTO
(X-ray
1.70A
)
6JTP
(X-ray
1.90A
)
6M9W
(X-ray
1.50A
)
6MBQ
(X-ray
1.35A
)
6MBT
(X-ray
1.45A
)
6MBU
(X-ray
1.45A
)
6MNX
(X-ray
2.20A
)
6MQG
(X-ray
1.50A
)
6MQN
(X-ray
1.60A
)
6MS9
(X-ray
1.49A
)
6MTA
(X-ray
2.15A
)
6N2J
(X-ray
1.80A
)
6N2K
(X-ray
1.72A
)
6O36
(X-ray
2.00A
)
6O46
(X-ray
1.90A
)
6O4Y
(X-ray
1.58A
)
6O4Z
(X-ray
1.50A
)
6O51
(X-ray
1.55A
)
6O53
(X-ray
1.40A
)
6OB2
(X-ray
2.85A
)
6OB3
(X-ray
2.10A
)
6OIM
(X-ray
1.65A
)
6P0Z
(X-ray
1.01A
)
6P8W
(X-ray
2.10A
)
6P8X
(X-ray
2.11A
)
6P8Y
(X-ray
2.31A
)
6P8Z
(X-ray
1.65A
)
6PGO
(X-ray
1.60A
)
6PGP
(X-ray
1.50A
)
6PQ3
(X-ray
1.75A
)
6PTS
(NMR
-
)
6PTW
(NMR
-
)
6QUU
(X-ray
1.48A
)
6QUV
(X-ray
1.48A
)
6QUW
(X-ray
1.24A
)
6QUX
(X-ray
1.62A
)
6T5B
(X-ray
1.37A
)
6T5U
(X-ray
1.72A
)
6T5V
(X-ray
1.31A
)
6TAM
(X-ray
1.64A
)
6TAN
(X-ray
1.16A
)
6USX
(X-ray
2.27A
)
6USZ
(X-ray
2.03A
)
6UT0
(X-ray
1.94A
)
6V5L
(NMR
-
)
6V65
(X-ray
2.76A
)
6V6F
(X-ray
2.54A
)
6VC8
(X-ray
2.50A
)
6VJJ
(X-ray
1.40A
)
6W4E
(NMR
-
)
6W4F
(NMR
-
)
6WGN
(X-ray
1.60A
)
6WS2
(X-ray
1.59A
)
6WS4
(X-ray
1.84A
)
6XGU
(X-ray
2.70A
)
6XGV
(X-ray
2.11A
)
6XHA
(X-ray
2.87A
)
6XHB
(X-ray
2.50A
)
6YR8
(X-ray
1.90A
)
6YXW
(X-ray
2.06A
)
6ZL5
(X-ray
1.65A
)
6ZLI
(X-ray
1.73A
)
7A1W
(X-ray
1.76A
)
7A1X
(X-ray
1.32A
)
7A1Y
(X-ray
2.00A
)
7A47
(X-ray
2.16A
)
7ACA
(X-ray
1.57A
)
7ACF
(X-ray
1.91A
)
7ACH
(X-ray
1.90A
)
7ACQ
(X-ray
1.86A
)
7C40
(X-ray
2.52A
)
7C41
(X-ray
2.28A
)
7EW9
(X-ray
2.13A
)
7EWA
(X-ray
2.25A
)
7EWB
(X-ray
1.99A
)
7EYX
(X-ray
1.82A
)
7F0W
(X-ray
1.39A
)
7KFZ
(EM
3.47A
)
7KMR
(X-ray
1.51A
)
7KYZ
(NMR
-
)
7LC1
(X-ray
2.35A
)
7LC2
(X-ray
2.70A
)
7LGI
(NMR
-
)
7LZ5
(X-ray
1.50A
)
7MDP
(X-ray
1.96A
)
7MQU
(NMR
-
)
7NY8
(X-ray
1.80A
)
7O70
(X-ray
1.18A
)
7OO7
(X-ray
1.48A
)
7Q9U
(X-ray
2.24A
)
7R0M
(X-ray
1.61A
)
7R0N
(X-ray
1.20A
)
7R0Q
(X-ray
1.95A
)
7ROV
(X-ray
1.32A
)
7RP2
(X-ray
2.20A
)
7RP3
(X-ray
2.00A
)
7RP4
(X-ray
2.15A
)
7RPZ
(X-ray
1.30A
)
7RSC
(NMR
-
)
7RSE
(NMR
-
)
7RT1
(X-ray
1.27A
)
7RT2
(X-ray
1.59A
)
7RT3
(X-ray
1.56A
)
7RT4
(X-ray
2.10A
)
7RT5
(X-ray
1.29A
)
7SCW
(X-ray
1.98A
)
7SCX
(X-ray
1.96A
)
7T47
(X-ray
1.27A
)
7TLE
(X-ray
1.99A
)
7TLG
(X-ray
1.80A
)
7TLK
(X-ray
1.71A
)
7VVB
(X-ray
1.70A
)
8DNI
(X-ray
1.50A
)
DBSNP
rs193929331
rs104894361
rs121913529
rs121913530
rs121913529
rs121913530
rs121913530
rs121913529
rs112445441
rs121913535
rs104894365
rs121913538
rs121913236
rs727503110
rs104894366
rs104894366
rs727503109
rs104894364
rs121913528
rs104894359
rs104894359
rs17851045
rs121913240
rs387907205
rs770248150
rs121913527
rs1057519725
rs387907206
rs104894367
rs104894360
rs397517042
rs104894362
Subcellular location [CC]
Cell membrane {ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:29239724};
Lipid-anchor {ECO:0000269|PubMed:29239724, ECO:0000305|PubMed:23698361};
Cytoplasmic side {ECO:0000305|PubMed:23698361}. Endomembrane system {ECO:0000269|PubMed:29239724}. Cytoplasm, cytosol {ECO:0000269|PubMed:23698361}.;
[Isoform 2B]: Cell membrane {ECO:0000269|PubMed:28619714};
Lipid-anchor {ECO:0000305|PubMed:28619714}.
Mouse PG classification
NA
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