| Gene Information | |
|---|---|
| Gene Name | KPNB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 876 |
| Protein Names | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000108424 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14974 |
| Gene Card | KPNB1 |
| Uniprot ID | Q14974 |
| Pfam | PF03810 |
| In ASD | no |
| Allosteric Prediction | yes (0.692809624) |
| Ortholog in Animals | Alpaca_ KPNB1 ( ortholog_one2one ) Dog_ KPNB1 ( ortholog_one2one ) GuineaPig_ KPNB1 ( ortholog_one2one ) Macaque_ KPNB1 ( ortholog_one2one ) Mouse_ Kpnb1 ( ortholog_one2one ) Pig_ KPNB1 ( ortholog_one2one ) Rat_ Kpnb1 ( ortholog_one2one ) Rabbit_ KPNB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNPO1, IPO5, TNPO2, RANBP6, IPO4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002124(Rat);0.055556(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1F59 (X-ray 2.80A ) 1IBR (X-ray 2.30A ) 1M5N (X-ray 2.90A ) 1O6O (X-ray 2.80A ) 1O6P (X-ray 2.80A ) 1QGK (X-ray 2.50A ) 1QGR (X-ray 2.30A ) 2P8Q (X-ray 2.35A ) 2Q5D (X-ray 3.20A ) 2QNA (X-ray 2.84A ) 3LWW (X-ray 3.15A ) 3W5K (X-ray 2.60A ) 6N88 (EM 6.20A ) 6N89 (EM 7.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11891849}. Nucleus envelope {ECO:0000269|PubMed:11891849}. |
| Mouse PG classification | NA |
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