| Gene Information | |
|---|---|
| Gene Name | KPNA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 521 |
| Protein Names | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000186432 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00629 |
| Gene Card | KPNA4 |
| Uniprot ID | O00629 |
| Pfam | PF00514; PF16186; PF01749 |
| In ASD | no |
| Allosteric Prediction | no (-0.999906347) |
| Ortholog in Animals | Alpaca_ KPNA4 ( ortholog_one2one ) Dog_ KPNA4 ( ortholog_one2one ) GuineaPig_ KPNA4 ( ortholog_one2one ) Macaque_ KPNA4 ( ortholog_one2one ) Mouse_ Kpna4 ( ortholog_one2one ) Pig_ KPNA4 ( ortholog_one2one ) Rat_ Kpna4 ( ortholog_one2one ) Rabbit_ KPNA4 ( ortholog_one2one ) |
| Ohnologs | KPNA3 |
| Paralogs | KPNA3, KPNA7, KPNA2, KPNA1, KPNA6, KPNA5 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001841(Rat);0.028(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UAE (X-ray 2.70A ) 5TBK (X-ray 3.45A ) 5XZX (X-ray 3.00A ) 6BVV (X-ray 2.30A ) 6BVZ (X-ray 2.30A ) 6BW9 (X-ray 1.60A ) 6BWA (X-ray 2.20A ) 6BWB (X-ray 2.30A ) 6WX8 (X-ray 2.30A ) 7JJL (X-ray 2.60A ) 7LF4 (X-ray 2.85A ) 7LFC (X-ray 2.10A ) 7RFY (X-ray 2.50A ) 7RG5 (X-ray 2.15A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Mouse PG classification | NA |
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