| Gene Information | |
|---|---|
| Gene Name | KPNA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 529 |
| Protein Names | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000182481 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P52292 |
| Gene Card | KPNA2 |
| Uniprot ID | P52292 |
| Pfam | PF00514; PF16186; PF01749 |
| In ASD | no |
| Allosteric Prediction | yes (0.519862822) |
| Ortholog in Animals | Alpaca_ KPNA2 ( ortholog_one2one ) Dog_ KPNA2 ( ortholog_one2many ) GuineaPig_ KPNA2 ( ortholog_one2one ) Macaque_ KPNA2 ( ortholog_one2one ) Mouse_ Kpna2 ( ortholog_one2many ) Mouse_ Gm10184 ( ortholog_one2many ) Pig_ KPNA2 ( ortholog_one2one ) Rat_ Kpna2 ( ortholog_one2many ) |
| Ohnologs | KPNA7, KPNA5 |
| Paralogs | KPNA7, KPNA3, KPNA4, KPNA1, KPNA6, KPNA5 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001194(Rat);0.024(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EFX (X-ray 3.00A ) 1QGK (X-ray 2.50A ) 1QGR (X-ray 2.30A ) 3FEX (X-ray 3.55A ) 3FEY (X-ray 2.20A ) 3WPT (X-ray 2.63A ) 4E4V (X-ray 2.53A ) 4WV6 (X-ray 1.75A ) 5H43 (X-ray 2.30A ) 7CRU (X-ray 2.80A ) 7N8J (X-ray 3.20A ) 7N9H (X-ray 2.20A ) |
| DBSNP | rs17850032 rs11545989 rs1059558 rs17850031 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:7604027}. Nucleus {ECO:0000269|PubMed:7604027}.; Endoplasmic reticulum membrane. Golgi apparatus membrane {ECO:0000269|PubMed:17596301}. Note=(Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. {ECO:0000269|PubMed:17596301}. |
| Mouse PG classification | NA |
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