Gene Information
Gene NameATL1
OrganismHomo sapiens (Human)
Gene Length558
Protein NamesAtlastin-1 (EC 3.6.5.-) (Brain-specific GTP-binding protein) (GTP-binding protein 3) (GBP-3) (hGBP3) (Guanine nucleotide-binding protein 3) (Spastic paraplegia 3 protein A)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000198513 )
Evolutionary StageEukaryota
AlphaFoldDBQ8WXF7
Gene CardATL1
Uniprot IDQ8WXF7
PfamPF02263
In ASDno
Allosteric Predictionno (-1.211802327)
Ortholog in AnimalsAlpaca_ ATL1 ( ortholog_one2one )
Dog_ ATL1 ( ortholog_one2one )
GuineaPig_ ATL1 ( ortholog_one2one )
Macaque_ ATL1 ( ortholog_one2one )
Mouse_ Atl1 ( ortholog_one2one )
Pig_ ATL1 ( ortholog_one2one )
Rat_ Atl1 ( ortholog_one2one )
Rabbit_ ATL1 ( ortholog_one2one )
OhnologsATL2, ATL3
ParalogsGBP5, ATL2, GBP7, ATL3, GBP2, GBP6, GBP1, RNF112, GBP4, GBP3
TissueNA
Tissue SpecificityExpressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level). {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3Q5D  (X-ray  2.70A  )  3Q5E  (X-ray  3.01A  )  3QNU  (X-ray  2.80A  )  3QOF  (X-ray  2.80A  )  4IDN  (X-ray  2.25A  )  4IDO  (X-ray  2.09A  )  4IDP  (X-ray  2.59A  )  4IDQ  (X-ray  2.30A  )  6B9D  (X-ray  1.95A  )  6B9E  (X-ray  1.99A  )  6B9F  (X-ray  1.90A  )  6B9G  (X-ray  3.00A  )  6XJN  (X-ray  2.20A  )  7OL3  (X-ray  1.90A  ) 
DBSNP rs17850684  rs200314808  rs606231265  rs119476051  rs17850683  rs1555364246  rs119476049  rs119476046  rs864622520  rs119476048  rs119476047  rs1555365597  rs28939094  rs397514712  rs119476050  rs387906941  rs1595625206  rs864622269 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:16339213, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977};
Multi-pass membrane protein {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:16339213, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:19665976}. Golgi apparatus membrane {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752};
Multi-pass membrane protein {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752}. Cell projection, axon {ECO:0000250|UniProtKB:Q6PST4}. Note=Localizes to endoplasmic reticulum tubular network (PubMed:27619977). {ECO:0000269|PubMed:27619977}.
Mouse PG classificationNA
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