| Gene Information | |
|---|---|
| Gene Name | LRIT3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 679 |
| Protein Names | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000183423 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q3SXY7 |
| Gene Card | LRIT3 |
| Uniprot ID | Q3SXY7 |
| Pfam | PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-1.039621086) |
| Ortholog in Animals | Alpaca_ LRIT3 ( ortholog_one2one ) Dog_ LRIT3 ( ortholog_one2one ) GuineaPig_ LRIT3 ( ortholog_one2one ) Macaque_ LRIT3 ( ortholog_one2one ) Mouse_ Lrit3 ( ortholog_one2one ) Pig_ LRIT3 ( ortholog_one2one ) Rat_ Lrit3 ( ortholog_one2one ) Rabbit_ LRIT3 ( ortholog_one2one ) |
| Ohnologs | LRIT1, LRFN4 |
| Paralogs | LRG1, CPN2, LRRTM2, LRRC52, LRRC24, ELFN2, LRIG3, LGR6, LGR5, CHAD, CHADL, LRIT1, TRIL, ELFN1, LGR4, LGI2, LGI1, LRIG2, LRRC26, LRIG1, LGI3, LGI4 |
| Tissue | NA |
| Tissue Specificity | Detected in the outer plexiform layer (OPL) of the retina where it localizes to ON-bipolar cells (at protein level). {ECO:0000269|PubMed:23246293}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4698797 rs376610215 rs764205 rs2347131 rs2347132 rs766899767 |
| Subcellular location [CC] | Cell projection, dendrite {ECO:0000269|PubMed:23246293}. Perikaryon {ECO:0000250|UniProtKB:W8DXL4}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Punctate expression at dendrite tips. {ECO:0000269|PubMed:23246293}. |
| Mouse PG classification | HPG |
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