| Gene Information | |
|---|---|
| Gene Name | KOC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 579 |
| Protein Names | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O00425 |
| Gene Card | IGF2BP3 |
| Uniprot ID | O00425 |
| Pfam | PF00013; PF00076 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. {ECO:0000269|PubMed:10525192, ECO:0000269|PubMed:12161597, ECO:0000269|PubMed:15644775, ECO:0000269|PubMed:16049158, ECO:0000269|PubMed:16814207, ECO:0000269|PubMed:17192788, ECO:0000269|PubMed:9178771, ECO:0000269|PubMed:9891060}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2E44 (NMR - ) 6FQ1 (X-ray 1.31A ) 6FQR (X-ray 2.10A ) 6GQE (X-ray 2.15A ) 6GX6 (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Cytoplasm. Cytoplasm, P-body {ECO:0000269|PubMed:29476152}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29476152}. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules. |
| Mouse PG classification | NA |
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