| Gene Information | |
|---|---|
| Gene Name | MAP2K3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 347 |
| Protein Names | Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) |
| Target Name | dual specificity mitogen-activated protein kinase kinase 3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000034152 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P46734 |
| Gene Card | MAP2K3 |
| Uniprot ID | P46734 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.966825041) |
| Ortholog in Animals | Dog_ MAP2K3 ( ortholog_one2one ) GuineaPig_ MAP2K3 ( ortholog_one2one ) Macaque_ MAP2K3 ( ortholog_one2one ) Mouse_ Map2k3 ( ortholog_one2one ) Pig_ MAP2K3 ( ortholog_one2one ) Rat_ Map2k3 ( ortholog_one2one ) Rabbit_ MAP2K3 ( ortholog_one2one ) |
| Ohnologs | MAP2K6 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs33911218 rs36047035 rs34105301 rs2305873 rs36076766 rs56067280 rs56216806 rs1339756947 rs989026404 rs35206134 rs2363198 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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