| Gene Information | |
|---|---|
| Gene Name | KNL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2342 |
| Protein Names | Kinetochore scaffold 1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000137812 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8NG31 |
| Gene Card | KNL1 |
| Uniprot ID | Q8NG31 |
| Pfam | PF18210; PF19221 |
| In ASD | no |
| Allosteric Prediction | yes (0.150732761) |
| Ortholog in Animals | Alpaca_ KNL1 ( ortholog_one2one ) Dog_ KNL1 ( ortholog_one2one ) GuineaPig_ KNL1 ( ortholog_one2one ) Macaque_ KNL1 ( ortholog_one2one ) Mouse_ Knl1 ( ortholog_one2one ) Rat_ Knl1 ( ortholog_one2one ) Rabbit_ KNL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis, brain |
| Tissue Specificity | Highly expressed in testis, where it is localized in germ cells, in particular in spermatocytes and in the pre-acrosome of round spermatids. Detected in the acrosome of ejaculated spermatozoa. Detected in adult thymus, bone marrow, colon, small intestine, appendix and placenta, and in fetal liver and thymus. {ECO:0000269|PubMed:10980622, ECO:0000269|PubMed:12087463, ECO:0000269|PubMed:12618768}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.052875(Rat);0.045455(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3SI5 (X-ray 2.20A ) 4A1G (X-ray 2.60A ) 4NF9 (X-ray 2.80A ) 4NFA (X-ray 2.50A ) |
| DBSNP | rs7177192 rs16970874 rs12911738 rs35146555 rs2412541 rs11858113 rs8040502 rs58614880 rs17747633 rs16970911 rs763915472 rs61164860 |
| Subcellular location [CC] | Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle. |
| Mouse PG classification | NA |
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