Gene Information
Gene NameKNG1
OrganismHomo sapiens (Human)
Gene Length644
Protein NamesKininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]
Target Namekininogen
Target TypeClinical trial target
Gene Age544 ( ENSG00000113889 )
Evolutionary StageVertebrata
AlphaFoldDBP01042
Gene CardKNG1
Uniprot IDP01042
PfamPF00031
In ASDno
Allosteric Predictionyes (2.096214024)
Ortholog in AnimalsAlpaca_ KNG1 ( ortholog_one2one )
Dog_ KNG1 ( ortholog_one2one )
GuineaPig_ KNG1 ( ortholog_one2one )
Macaque_ KNG1 ( ortholog_one2one )
Mouse_ Kng1 ( ortholog_one2many )
Mouse_ Kng2 ( ortholog_one2many )
Pig_ KNG1 ( ortholog_one2one )
Rat_ Kng1 ( ortholog_one2many )
Rat_ Kng2l1 ( ortholog_one2many )
Rabbit_ KNG1 ( ortholog_one2one )
OhnologsNA
ParalogsHRG, FETUB, AHSG
Tissueliver, kidney
Tissue SpecificitySecreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269|PubMed:2076202}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1NY2  (X-ray  2.30A  )  2WOK  (X-ray  1.70A  )  4ASQ  (X-ray  1.99A  )  4ASR  (X-ray  1.90A  )  4ECB  (X-ray  2.20A  )  4ECC  (X-ray  2.20A  )  5I25  (X-ray  2.85A  )  6F27  (NMR  -  )  6F3V  (NMR  -  )  6F3W  (NMR  -  )  6F3X  (NMR  -  )  6F3Y  (NMR  -  )  7EIB  (EM  3.00A  )  7F2O  (EM  2.90A  )  7F6H  (EM  2.90A  )  7F6I  (EM  2.80A  ) 
DBSNP rs5030015  rs1656922  rs2304456  rs5030024  rs5030084  rs710446  rs5030087 
Subcellular location [CC]Secreted, extracellular space.
Mouse PG classificationNA
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