| Gene Information | |
|---|---|
| Gene Name | KNG |
| Organism | Homo sapiens (Human) |
| Gene Length | 644 |
| Protein Names | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P01042 |
| Gene Card | KNG1 |
| Uniprot ID | P01042 |
| Pfam | PF00031 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269|PubMed:2076202}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NY2 (X-ray 2.30A ) 2WOK (X-ray 1.70A ) 4ASQ (X-ray 1.99A ) 4ASR (X-ray 1.90A ) 4ECB (X-ray 2.20A ) 4ECC (X-ray 2.20A ) 5I25 (X-ray 2.85A ) 6F27 (NMR - ) 6F3V (NMR - ) 6F3W (NMR - ) 6F3X (NMR - ) 6F3Y (NMR - ) 7EIB (EM 3.00A ) 7F2O (EM 2.90A ) 7F6H (EM 2.90A ) 7F6I (EM 2.80A ) |
| DBSNP | rs5030015 rs1656922 rs2304456 rs5030024 rs5030084 rs710446 rs5030087 |
| Subcellular location [CC] | Secreted, extracellular space. |
| Mouse PG classification | NA |
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