| Gene Information | |
|---|---|
| Gene Name | KMT5C |
| Organism | Homo sapiens (Human) |
| Gene Length | 462 |
| Protein Names | Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) |
| Target Name | histone-lysine n-methyltransferase kmt5c |
| Target Type | Preclinical target |
| Gene Age | 544 ( ENSG00000133247 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q86Y97 |
| Gene Card | KMT5C |
| Uniprot ID | Q86Y97 |
| Pfam | PF00856 |
| In ASD | no |
| Allosteric Prediction | no (-1.11419951) |
| Ortholog in Animals | Alpaca_ KMT5C ( ortholog_one2one ) Dog_ KMT5C ( ortholog_one2one ) GuineaPig_ KMT5C ( ortholog_one2one ) Macaque_ KMT5C ( ortholog_one2one ) Mouse_ Kmt5c ( ortholog_one2one ) Pig_ KMT5C ( ortholog_one2one ) Rat_ Kmt5c ( ortholog_one2one ) |
| Ohnologs | KMT5B |
| Paralogs | KMT5B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3RQ4 (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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