| Gene Information | |
|---|---|
| Gene Name | PPP2R5A |
| Organism | Homo sapiens (Human) |
| Gene Length | 486 |
| Protein Names | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) |
| Target Name | pp2a b subunit isoform r5-alpha |
| Target Type | Literature-reported target |
| Gene Age | >4290 ( ENSG00000066027 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15172 |
| Gene Card | PPP2R5A |
| Uniprot ID | Q15172 |
| Pfam | PF01603 |
| In ASD | no |
| Allosteric Prediction | yes (0.567260129) |
| Ortholog in Animals | Alpaca_ PPP2R5A ( ortholog_one2one ) Dog_ PPP2R5A ( ortholog_one2one ) GuineaPig_ PPP2R5A ( ortholog_one2one ) Macaque_ PPP2R5A ( ortholog_one2one ) Mouse_ Ppp2r5a ( ortholog_one2one ) Pig_ PPP2R5A ( ortholog_one2one ) Rat_ Ppp2r5a ( ortholog_one2one ) Rabbit_ PPP2R5A ( ortholog_one2one ) |
| Ohnologs | PPP2R5B, PPP2R5E |
| Paralogs | PPP2R5B, PPP2R5E, PPP2R5D, PPP2R5C |
| Tissue | NA |
| Tissue Specificity | Widely expressed with the highest expression in heart and skeletal muscle. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6NTS (EM 3.63A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:8703017}. Nucleus {ECO:0000269|PubMed:8703017}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. {ECO:0000269|PubMed:16541025}. |
| Mouse PG classification | NA |
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