| Gene Information | |
|---|---|
| Gene Name | KMT2E |
| Organism | Homo sapiens (Human) |
| Gene Length | 1858 |
| Protein Names | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000005483 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8IZD2 |
| Gene Card | KMT2E |
| Uniprot ID | Q8IZD2 |
| Pfam | PF00628; PF00856 |
| In ASD | no |
| Allosteric Prediction | yes (0.146962632) |
| Ortholog in Animals | Alpaca_ KMT2E ( ortholog_one2one ) Dog_ KMT2E ( ortholog_one2one ) Macaque_ KMT2E ( ortholog_one2one ) Mouse_ Kmt2e ( ortholog_one2one ) Pig_ KMT2E ( ortholog_one2one ) Rat_ Kmt2e ( ortholog_one2one ) Rabbit_ KMT2E ( ortholog_one2one ) |
| Ohnologs | SETD5 |
| Paralogs | SETD5 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in both adult and fetal tissues (PubMed:12101424, PubMed:23958951). Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum (PubMed:12101424, PubMed:23958951). Isoform NKp44L: Not detected on circulating cells from healthy individuals, but is expressed on a large panel of tumor and transformed cells (PubMed:23958951). {ECO:0000269|PubMed:12101424, ECO:0000269|PubMed:23958951}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LV9 (NMR - ) 4L58 (X-ray 1.48A ) 5HT6 (X-ray 2.09A ) |
| DBSNP | rs35605511 |
| Subcellular location [CC] | Chromosome {ECO:0000269|PubMed:23798402}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23798402}. Nucleus speckle {ECO:0000269|PubMed:14718661}. Note=Absent from the nucleolus (PubMed:14718661). Localizes to chromosome during interphase and to centrosomes during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' (PubMed:23798402). {ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:23798402}.; [Isoform 3]: Nucleus, nucleoplasm {ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26678539}. Nucleus speckle {ECO:0000269|PubMed:23798402}. Note=Absent from the nucleolus (PubMed:23629655). Localizes to chromosome during interphase and to nucleus speckle during mitosis (PubMed:23798402). Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' (PubMed:23798402). {ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402}.; [Isoform NKp44L]: Cytoplasm {ECO:0000269|PubMed:23958951}. Cell membrane {ECO:0000269|PubMed:23958951}; Peripheral membrane protein {ECO:0000269|PubMed:23958951}. |
| Mouse PG classification | NA |
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