| Gene Information | |
|---|---|
| Gene Name | KMT1E |
| Organism | Homo sapiens (Human) |
| Gene Length | 1291 |
| Protein Names | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q15047 |
| Gene Card | SETDB1 |
| Uniprot ID | Q15047 |
| Pfam | PF18300; PF01429; PF05033; PF00856; PF18358; PF18359 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High expression in testis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.007512(Rat);0.008501(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3DLM (X-ray 1.77A ) 4X3S (X-ray 1.60A ) 5KCH (X-ray 1.70A ) 5KCO (X-ray 1.47A ) 5KE2 (X-ray 1.56A ) 5KE3 (X-ray 1.70A ) 5KH6 (X-ray 2.05A ) 5QT1 (X-ray 1.58A ) 5QT2 (X-ray 1.59A ) 6AU2 (X-ray 1.63A ) 6AU3 (X-ray 1.80A ) 6BHD (X-ray 1.25A ) 6BHE (X-ray 1.35A ) 6BHG (X-ray 1.45A ) 6BHH (X-ray 1.85A ) 6BHI (X-ray 1.40A ) 6BPI (X-ray 1.64A ) 7C9N (X-ray 2.47A ) 7CAJ (X-ray 2.20A ) 7CD9 (X-ray 1.60A ) 7CJT (X-ray 2.47A ) |
| DBSNP | rs2271075 rs17852587 rs2691551 rs2814054 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:27732843}. Cytoplasm {ECO:0000269|PubMed:27732843}. Chromosome. Note=Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin. {ECO:0000269|PubMed:27732843}. |
| Mouse PG classification | NA |
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