| Gene Information | |
|---|---|
| Gene Name | KLRG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 195 |
| Protein Names | Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000139187 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96E93 |
| Gene Card | KLRG1 |
| Uniprot ID | Q96E93 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.582374536) |
| Ortholog in Animals | Alpaca_ KLRG1 ( ortholog_one2one ) Dog_ KLRG1 ( ortholog_one2one ) GuineaPig_ KLRG1 ( ortholog_one2one ) Macaque_ KLRG1 ( ortholog_one2one ) Mouse_ Klrg1 ( ortholog_one2one ) Pig_ KLRG1 ( ortholog_one2one ) Rat_ Klrg1 ( ortholog_one2one ) Rabbit_ KLRG1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD69, CLEC12A, KLRC3, KLRC2, CLEC12B, OLR1, KLRG2, CLEC2A, KLRF1, CLEC1A, KLRF2, KLRD1, CLEC2B, KLRC1, CLEC2L, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC5A, CLEC2D, CLEC7A, KLRB1 |
| Tissue | NA |
| Tissue Specificity | Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. {ECO:0000269|PubMed:15879103, ECO:0000269|PubMed:9842918}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FF7 (X-ray 1.80A ) |
| DBSNP | rs1805749 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}. |
| Mouse PG classification | NA |
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