| Gene Information | |
|---|---|
| Gene Name | KLRF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 231 |
| Protein Names | Killer cell lectin-like receptor subfamily F member 1 (Lectin-like receptor F1) (Activating coreceptor NKp80) (C-type lectin domain family 5 member C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000150045 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NZS2 |
| Gene Card | KLRF1 |
| Uniprot ID | Q9NZS2 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-1.732961725) |
| Ortholog in Animals | Alpaca_ KLRF1 ( ortholog_one2one ) Dog_ KLRF1 ( ortholog_one2one ) Macaque_ KLRF1 ( ortholog_one2one ) Pig_ KLRF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CD69, CLEC12A, KLRC3, KLRC2, CLEC12B, OLR1, KLRG2, CLEC2A, CLEC1A, KLRF2, KLRD1, CLEC2B, KLRC1, CLEC2L, KLRG1, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC5A, CLEC2D, CLEC7A, KLRB1 |
| Tissue | bone.marrow, spleen, lung |
| Tissue Specificity | Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes. {ECO:0000269|PubMed:10671213}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2232548 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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