Gene Information
Gene NameKLRC2
OrganismHomo sapiens (Human)
Gene Length231
Protein NamesNKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000205809 )
Evolutionary StageMammalia
AlphaFoldDBP26717
Gene CardKLRC2
Uniprot IDP26717
PfamPF00059
In ASDno
Allosteric Predictionno (-0.664206223)
Ortholog in AnimalsMouse_ Klrh1 ( ortholog_many2many )
Mouse_ Clec2m ( ortholog_many2many )
Mouse_ Klri1 ( ortholog_many2many )
Mouse_ Klri2 ( ortholog_many2many )
Mouse_ Klre1 ( ortholog_many2many )
Rat_ Klrh1 ( ortholog_many2many )
Rat_ RGD1564770 ( ortholog_many2many )
Rat_ Klri1 ( ortholog_many2many )
Rat_ Klri2 ( ortholog_many2many )
Rat_ Klre1 ( ortholog_many2many )
OhnologsNA
ParalogsCD69, CLEC12A, CLEC12B, OLR1, KLRG2, CLEC2A, KLRF1, CLEC1A, KLRF2, KLRD1, CLEC2B, KLRC1, CLEC2L, KLRG1, CLEC9A, CLEC1B, KLRC4, KLRK1, CLEC5A, CLEC2D, CLEC7A, KLRB1, KLRC3
TissueNA
Tissue SpecificityExpressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level) (PubMed:20952657, PubMed:21825173). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level) (PubMed:20952657). Expressed in alpha-beta T cells subsets (at protein level) (PubMed:20952657). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed within NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657). {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2L35  (NMR  -  ) 
DBSNP rs28403159  rs1141715 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173};
Single-pass type II membrane protein {ECO:0000255}.
Mouse PG classificationNA
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