| Gene Information | |
|---|---|
| Gene Name | THAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 213 |
| Protein Names | THAP domain-containing protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000131931 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NVV9 |
| Gene Card | THAP1 |
| Uniprot ID | Q9NVV9 |
| Pfam | PF05485 |
| In ASD | no |
| Allosteric Prediction | no (-1.148850472) |
| Ortholog in Animals | Alpaca_ THAP1 ( ortholog_one2one ) Dog_ THAP1 ( ortholog_one2one ) GuineaPig_ THAP1 ( ortholog_one2one ) Macaque_ THAP1 ( ortholog_one2one ) Mouse_ Thap1 ( ortholog_one2one ) Pig_ THAP1 ( ortholog_one2one ) Rat_ Thap1 ( ortholog_one2one ) Rabbit_ THAP1 ( ortholog_one2one ) |
| Ohnologs | THAP2 |
| Paralogs | ARL14EP, THAP8, THAP7, ARL14EPL, THAP2, THAP6, THAP3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. {ECO:0000269|PubMed:20200153}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JTG (NMR - ) 2KO0 (NMR - ) 2L1G (NMR - ) |
| DBSNP | rs1586459410 rs267607112 rs766483829 rs387907177 rs387907176 rs1802674870 rs767952378 rs372080941 rs118204013 rs768017019 rs267607111 rs950435041 rs769988455 rs374512193 rs138918468 rs767519301 rs759392096 rs377725442 |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000269|PubMed:12717420}. Nucleus, PML body {ECO:0000269|PubMed:12717420}. |
| Mouse PG classification | NA |
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