| Gene Information | |
|---|---|
| Gene Name | KLK8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 260 |
| Protein Names | Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000129455 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O60259 |
| Gene Card | KLK8 |
| Uniprot ID | O60259 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.202108804) |
| Ortholog in Animals | Alpaca_ KLK8 ( ortholog_one2one ) Dog_ KLK8 ( ortholog_one2one ) GuineaPig_ KLK8 ( ortholog_one2one ) Mouse_ Klk8 ( ortholog_one2one ) Pig_ KLK8 ( ortholog_one2one ) Rat_ Klk8 ( ortholog_one2one ) Rabbit_ KLK8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KLK3, KLK2, KLK1, KLK7, KLK4, KLK5, KLK11, KLK14, KLK12, PRSS58, TMPRSS4, PRSS54 |
| Tissue | esophagus, skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. {ECO:0000269|PubMed:11309326, ECO:0000269|PubMed:11522960, ECO:0000269|PubMed:12147714, ECO:0000269|PubMed:17761692}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5MS3 (X-ray 2.30A ) 5MS4 (X-ray 2.10A ) |
| DBSNP | rs16988799 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:17761692}. Cytoplasm {ECO:0000269|PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes. |
| Mouse PG classification | NA |
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