Gene Information
Gene NameKLK7
OrganismHomo sapiens (Human)
Gene Length253
Protein NamesKallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)
Target Namekallikrein-7
Target TypeNA
Gene Age244 ( ENSG00000169035 )
Evolutionary StageEukaryota
AlphaFoldDBP49862
Gene CardKLK7
Uniprot IDP49862
PfamPF00089
In ASDno
Allosteric Predictionno (-0.397824411)
Ortholog in AnimalsAlpaca_ KLK7 ( ortholog_one2one )
Dog_ KLK7 ( ortholog_one2one )
GuineaPig_ KLK7 ( ortholog_one2one )
Macaque_ KLK8 ( ortholog_one2one )
Mouse_ Klk7 ( ortholog_one2one )
Pig_ KLK7 ( ortholog_one2one )
Rat_ Klk7 ( ortholog_one2one )
Rabbit_ KLK7 ( ortholog_one2one )
OhnologsNA
ParalogsKLK4, KLK5, KLK3, KLK2, KLK8, KLK1, KLK11, KLK14, KLK12, PRSS58, TMPRSS4, PRSS54
Tissueskin, tongue, zone.of.skin, lower.leg.skin, suprapubic.skin
Tissue SpecificityAbundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). {ECO:0000269|PubMed:10974542, ECO:0000269|PubMed:12738725}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2QXG  (X-ray  2.60A  )  2QXH  (X-ray  2.00A  )  2QXI  (X-ray  1.00A  )  2QXJ  (X-ray  2.10A  )  3BSQ  (X-ray  2.80A  )  5FAH  (X-ray  1.10A  )  5Y9L  (X-ray  2.15A  )  5YJK  (X-ray  2.40A  )  6SHH  (X-ray  2.00A  )  6SHI  (X-ray  1.85A  )  6SJU  (X-ray  1.97A  )  6Y4S  (X-ray  2.23A  ) 
DBSNP NA 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:12738725}. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
Mouse PG classificationNA
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