| Gene Information | |
|---|---|
| Gene Name | KLK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 293 |
| Protein Names | Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme) |
| Target Name | kallikrein-5 |
| Target Type | Patented-recorded target |
| Gene Age | 244 ( ENSG00000167754 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9Y337 |
| Gene Card | KLK5 |
| Uniprot ID | Q9Y337 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.466910445) |
| Ortholog in Animals | Alpaca_ KLK5 ( ortholog_one2one ) Macaque_ KLK5 ( ortholog_one2one ) Mouse_ Klk5 ( ortholog_one2one ) Pig_ KLK5 ( ortholog_one2one ) Rat_ Klk5 ( ortholog_one2one ) Rabbit_ KLK5 ( ortholog_one2one ) |
| Ohnologs | PRSS3, PRSS3P4, PRSS1 |
| Paralogs | KLK4, KLK7, KLK3, KLK2, KLK8, KLK1, KLK11, KLK14, KLK12, PRSS58, TMPRSS4, PRSS54 |
| Tissue | skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin. {ECO:0000269|PubMed:19190773}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2PSX (X-ray 2.30A ) 2PSY (X-ray 2.30A ) 6QFE (X-ray 1.67A ) |
| DBSNP | rs2232532 rs183854 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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