| Gene Information | |
|---|---|
| Gene Name | KLK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 261 |
| Protein Names | Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase) |
| Target Name | prostate-specific antigen |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000142515 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P07288 |
| Gene Card | KLK3 |
| Uniprot ID | P07288 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (1.03853419) |
| Ortholog in Animals | Alpaca_ KLK3 ( ortholog_one2one ) Dog_ KLK2 ( ortholog_one2many ) Macaque_ KLK3 ( ortholog_one2one ) Mouse_ Klk1 ( ortholog_many2many ) Mouse_ Klk1b27 ( ortholog_many2many ) Mouse_ Klk1b4 ( ortholog_many2many ) Mouse_ Klk1b8 ( ortholog_many2many ) Mouse_ Klk1b9 ( ortholog_many2many ) Mouse_ Klk1b24 ( ortholog_many2many ) Mouse_ Klk1b26 ( ortholog_many2many ) Mouse_ Klk1b16 ( ortholog_many2many ) Mouse_ Klk1b11 ( ortholog_many2many ) Mouse_ Klk1b22 ( ortholog_many2many ) Mouse_ Klk1b5 ( ortholog_many2many ) Mouse_ Klk1b21 ( ortholog_many2many ) Mouse_ Klk1b1 ( ortholog_many2many ) Mouse_ Klk1b3 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | KLK2, KLK1, KLK8, KLK7, KLK4, KLK5, KLK11, KLK14, KLK12, PRSS58, TMPRSS4, PRSS54 |
| Tissue | prostate |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZCH (X-ray 2.83A ) 2ZCK (X-ray 3.10A ) 2ZCL (X-ray 3.25A ) 3QUM (X-ray 3.20A ) |
| DBSNP | rs2271092 rs2003783 rs17632542 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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