| Gene Information | |
|---|---|
| Gene Name | KLK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 638 |
| Protein Names | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] |
| Target Name | prostate specific antigen |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000142515 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P03952 |
| Gene Card | KLKB1 |
| Uniprot ID | P03952 |
| Pfam | PF00024; PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (1.03853419) |
| Ortholog in Animals | Alpaca_ KLK3 ( ortholog_one2one ) Dog_ KLK2 ( ortholog_one2many ) Macaque_ KLK3 ( ortholog_one2one ) Mouse_ Klk1 ( ortholog_many2many ) Mouse_ Klk1b27 ( ortholog_many2many ) Mouse_ Klk1b4 ( ortholog_many2many ) Mouse_ Klk1b8 ( ortholog_many2many ) Mouse_ Klk1b9 ( ortholog_many2many ) Mouse_ Klk1b24 ( ortholog_many2many ) Mouse_ Klk1b26 ( ortholog_many2many ) Mouse_ Klk1b16 ( ortholog_many2many ) Mouse_ Klk1b11 ( ortholog_many2many ) Mouse_ Klk1b22 ( ortholog_many2many ) Mouse_ Klk1b5 ( ortholog_many2many ) Mouse_ Klk1b21 ( ortholog_many2many ) Mouse_ Klk1b1 ( ortholog_many2many ) Mouse_ Klk1b3 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | KLK2, KLK1, KLK8, KLK7, KLK4, KLK5, KLK11, KLK14, KLK12, PRSS58, TMPRSS4, PRSS54 |
| Tissue | prostate |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ANW (X-ray 1.85A ) 2ANY (X-ray 1.40A ) 4OGX (X-ray 2.40A ) 4OGY (X-ray 2.10A ) 5F8T (X-ray 1.75A ) 5F8X (X-ray 1.55A ) 5F8Z (X-ray 1.50A ) 5TJX (X-ray 1.41A ) 6I44 (X-ray 1.36A ) 6O1G (X-ray 2.20A ) 6O1S (X-ray 1.70A ) 6T7P (X-ray 1.42A ) 7N7X (X-ray 2.10A ) |
| DBSNP | rs121964952 rs3733402 rs4253257 rs4253373 rs145640112 rs2278542 rs4253376 rs4253377 rs4253379 rs4253301 rs4253316 rs121964951 rs4253325 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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