| Gene Information | |
|---|---|
| Gene Name | STK10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 968 |
| Protein Names | Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) |
| Target Name | serine/threonine-protein kinase 10 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000072786 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94804 |
| Gene Card | STK10 |
| Uniprot ID | O94804 |
| Pfam | PF00069; PF12474 |
| In ASD | no |
| Allosteric Prediction | no (-0.019890099) |
| Ortholog in Animals | Alpaca_ STK10 ( ortholog_one2one ) Dog_ STK10 ( ortholog_one2one ) GuineaPig_ STK10 ( ortholog_one2one ) Macaque_ STK10 ( ortholog_one2one ) Mouse_ Stk10 ( ortholog_one2one ) Pig_ STK10 ( ortholog_one2one ) Rat_ Stk10 ( ortholog_one2one ) Rabbit_ STK10 ( ortholog_one2one ) |
| Ohnologs | SLK |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. {ECO:0000269|PubMed:12639966}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2J7T (X-ray 2.00A ) 4AOT (X-ray 2.33A ) 4BC6 (X-ray 2.20A ) 4EQU (X-ray 2.00A ) 4USD (X-ray 3.05A ) 4USE (X-ray 2.65A ) 5AJQ (X-ray 2.20A ) 5OWQ (X-ray 2.70A ) 5OWR (X-ray 2.30A ) 6EIM (X-ray 1.43A ) 6GTT (X-ray 2.25A ) 6HXF (X-ray 2.09A ) 6I2Y (X-ray 2.56A ) 7QGP (X-ray 1.90A ) |
| DBSNP | rs35826078 rs757545210 rs56214442 rs55972616 rs56063773 rs34505340 rs17074311 rs34936670 rs56066852 rs55791916 rs1128204 rs56355550 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19255442}; Peripheral membrane protein {ECO:0000269|PubMed:19255442}. |
| Mouse PG classification | NA |
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