| Gene Information | |
|---|---|
| Gene Name | KLK11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 282 |
| Protein Names | Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000167757 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9UBX7 |
| Gene Card | KLK11 |
| Uniprot ID | Q9UBX7 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.841510291) |
| Ortholog in Animals | Alpaca_ KLK11 ( ortholog_one2one ) Dog_ KLK11 ( ortholog_one2one ) Macaque_ KLK11 ( ortholog_one2one ) Mouse_ Klk11 ( ortholog_one2one ) Pig_ KLK11 ( ortholog_one2one ) Rat_ Klk11 ( ortholog_one2one ) Rabbit_ KLK11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KLK12, KLK14, KLK7, KLK3, KLK2, KLK8, KLK4, KLK5, KLK1, PRSS58, TMPRSS4, PRSS54 |
| Tissue | esophagus.mucosa, lower.leg.skin, minor.salivary.gland, stomach, suprapubic.skin, vagina |
| Tissue Specificity | Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). {ECO:0000269|PubMed:10872828, ECO:0000269|PubMed:16467084}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2288892 rs3745539 rs1048328 |
| Subcellular location [CC] | [Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus. |
| Mouse PG classification | NA |
| click here to return to the previous page | |