| Gene Information | |
|---|---|
| Gene Name | KLK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 262 |
| Protein Names | Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein) |
| Target Name | tissue kallikrein |
| Target Type | Literature-reported target |
| Gene Age | 78 ( ENSG00000167748 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P06870 |
| Gene Card | KLK1 |
| Uniprot ID | P06870 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.534522109) |
| Ortholog in Animals | Alpaca_ KLK1 ( ortholog_one2one ) Macaque_ KLK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KLK3, KLK2, KLK8, KLK7, KLK4, KLK5, KLK11, KLK14, KLK12, PRSS58, TMPRSS4, PRSS54 |
| Tissue | pancreas, salivary.gland |
| Tissue Specificity | Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. {ECO:0000269|PubMed:7749372}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1SPJ (X-ray 1.70A ) |
| DBSNP | rs5515 rs5516 rs5517 rs5518 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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