| Gene Information | |
|---|---|
| Gene Name | SIRT6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 355 |
| Protein Names | NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000077463 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q8N6T7 |
| Gene Card | SIRT6 |
| Uniprot ID | Q8N6T7 |
| Pfam | PF02146 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999988454) |
| Ortholog in Animals | Alpaca_ SIRT6 ( ortholog_one2one ) Dog_ SIRT6 ( ortholog_one2one ) Macaque_ SIRT6 ( ortholog_one2one ) Mouse_ Sirt6 ( ortholog_one2one ) Pig_ SIRT6 ( ortholog_one2one ) Rat_ Sirt6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SIRT7, SIRT2, SIRT4, SIRT1, SIRT3, SIRT5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3K35 (X-ray 2.00A ) 3PKI (X-ray 2.04A ) 3PKJ (X-ray 2.12A ) 3ZG6 (X-ray 2.20A ) 5MF6 (X-ray 1.87A ) 5MFP (X-ray 1.98A ) 5MFZ (X-ray 2.10A ) 5MGN (X-ray 2.07A ) 5X16 (X-ray 1.97A ) 5Y2F (X-ray 2.53A ) 6HOY (X-ray 1.70A ) 6QCD (X-ray 1.84A ) 6QCE (X-ray 1.90A ) 6QCH (X-ray 2.10A ) 6QCJ (X-ray 2.01A ) 6XUY (X-ray 2.13A ) 6XV1 (X-ray 1.95A ) 6XV6 (X-ray 1.75A ) 6XVG (X-ray 2.10A ) 6ZU4 (X-ray 2.46A ) 7CL0 (X-ray 2.53A ) 7CL1 (X-ray 3.20A ) |
| DBSNP | rs352493 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:19135889, ECO:0000269|PubMed:26456828, ECO:0000269|PubMed:26898756, ECO:0000269|PubMed:29555651}. Chromosome {ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:26456828, ECO:0000269|PubMed:27043296, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:27912097, ECO:0000269|PubMed:31995034, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:32789493}. Chromosome, telomere {ECO:0000269|PubMed:18337721}. Endoplasmic reticulum {ECO:0000269|PubMed:23552949}. Note=Predominantly nuclear (PubMed:18337721). Associated with pericentric heterochromatin and telomeric heterochromatin regions (PubMed:18337721, PubMed:27043296). Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (PubMed:21680843, PubMed:23911928, PubMed:27568560, PubMed:31995034, PubMed:32538779). A fraction localizes to the endoplasmic reticulum (PubMed:23552949). {ECO:0000269|PubMed:18337721, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:23552949, ECO:0000269|PubMed:23911928, ECO:0000269|PubMed:27043296, ECO:0000269|PubMed:27568560, ECO:0000269|PubMed:31995034, ECO:0000269|PubMed:32538779}. |
| Mouse PG classification | NA |
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